为什么β细胞会在2型糖尿病中停止释放胰岛素

时间:2019-07-15 来源:www.smalldigitalcameracentral.com

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超级连接的“领导者”细胞协调胰岛素反应并帮助我们了解糖尿病的发展。

由于细胞中胰岛素抵抗的增加,2型糖尿病患者的血糖水平升高,具有深远的影响。经过多年的疾病,胰岛素会产生干燥,患者必须注射胰岛素。

是什么原因导致2型糖尿病患者缺乏胰岛素?来自德累斯顿理工大学(TUD)再生治疗中心(CRTD)的研究人员和伦敦帝国理工学院的同事以及英国,加拿大和意大利的其他研究机构观察到显着的细胞相互作用:胰岛β细胞作为高度连接簇,称为胰岛,应对小型“领先细胞”团队血糖水平的上升。科学家在“自然代谢”杂志上发表了他们的发现。

伦敦帝国理工学院教授Guy Rutter和David Hodson教授(现为英国伯明翰大学)的共同作者之前的工作证明,孤立的组织可能就是这种情况。为了证明活体动物,包括斑马鱼和老鼠,研究团队开发了一种创新的成像技术,使他们能够观察体内β细胞的层次关系。

“在这些模式生物中,我们看到当血糖水平升高时,β细胞反应来自时间确定的前导细胞。当我们选择性地去除前导细胞时,葡萄糖反应中随后的协调水平是破坏,”CRTD解释说。博士生Luis Delgadillo Silva,该研究的两位主要作者之一。数学分析表明,前导细胞对胰岛具有控制作用。此外,研究人员还能够证明一些β细胞含有独特的分子特征,使其具有更高的代谢活性,并可能对葡萄糖更敏感。

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Research by Imperial College London and Dresden University of Technology/CRTD scientists and colleagues from other research institutions in the UK, Canada and Italy is published on the cover of the scientific journal “Natural Metabolism”.

Based on their findings, scientists will now study the importance of leading cells in the development of diabetes. “For us, it is important to understand whether prostate cells are susceptible to the development of diabetes. It is vital that they are targets for maintaining a strong and healthy insulin response to help cure the disease,” Senior Clinical Research Victoria Dr. Salem explained. A researcher in the Investigative Medicine Division of Imperial College London, he is a co-leader of British research.

“To better understand the role of leader cells in islet function, we have established a new set of tools in zebrafish that will help us activate or silence beta cells by illuminating them and track individual cells over time. Using these tools, we will be able to pinpoint exactly how many cells are controlled by the leader cells and which genes determine the characteristics of the leader cells," Luis Delgadillo Silva said. #清风计划#

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